Experimental Helicobacter pylori infection in humans: a multifaceted challenge

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Experimental Helicobacter pylori infection in humans: a multifaceted challenge.

These include: References http://gut.bmjjournals.com/cgi/content/full/53/9/1224#BIBL This article cites 37 articles, 11 of which can be accessed free at: Rapid responses http://gut.bmjjournals.com/cgi/eletter-submit/53/9/1224 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign up in the box...

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STOMACH Challenge model for Helicobacter pylori infection in human volunteers

Background: A reliable challenge model is needed to evaluate Helicobacter pylori vaccine candidates. Methods: A cag pathogenicity island negative, OipA positive, multiple antibiotic susceptible strain of H pylori obtained from an individual with mild gastritis (Baylor strain 100) was used to challenge volunteers. Volunteers received 40 mg of famotidine at bedtime and 10–10 cfu of H pylori in be...

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Challenge model for Helicobacter pylori infection in human volunteers.

BACKGROUND A reliable challenge model is needed to evaluate Helicobacter pylori vaccine candidates. METHODS A cag pathogenicity island negative, OipA positive, multiple antibiotic susceptible strain of H pylori obtained from an individual with mild gastritis (Baylor strain 100) was used to challenge volunteers. Volunteers received 40 mg of famotidine at bedtime and 10(4)-10(10) cfu of H pylor...

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B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans.

The acute antibody and T-cell immune response to Helicobacter pylori infection in humans has not been studied systematically. Serum from H. pylori-naive volunteers challenged with H. pylori and cured after 4 or 12 weeks was tested by enzyme-linked immunosorbent assays for anti-H. pylori-specific immunoglobulin M (IgM) and IgA established using bacterial lysates from homologous (the infecting st...

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ژورنال

عنوان ژورنال: Gut

سال: 2004

ISSN: 0017-5749

DOI: 10.1136/gut.2004.042135